From the very beginning of time human beings have been responsible for their decisions. Whether good or bad. Without the help of God’s Holy Spirit people cannot regulate their lives in a manner that brings about real lasting change and happiness. Without the Holy Spirit mankind does not have the capacity to please God and can never inherit Eternal Life. But God has a God has a process that He uses to call people into a relationship with Him and Jesus Christ. It's found in John 6:44, 65.